Determining target engagement in living systems
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چکیده
منابع مشابه
Target engagement and drug residence time can be observed in living cells with BRET
The therapeutic action of drugs is predicated on their physical engagement with cellular targets. Here we describe a broadly applicable method using bioluminescence resonance energy transfer (BRET) to reveal the binding characteristics of a drug with selected targets within intact cells. Cell-permeable fluorescent tracers are used in a competitive binding format to quantify drug engagement with...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2013
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.1211